2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163038
    Sulfamethoxazole-NO hydrate
    Sulfamethoxazole-NO (SMX-NO) hydrate is the reactive metabolite of SMX (HY-B0322). Sulfamethoxazole-NO (SMX-NO) hydrate actis as a typical hapten and is capable of covalently modifying the MHC-peptide complex, can stimulate hapten-reactive T cells.
    Sulfamethoxazole-NO hydrate
  • HY-N8341
    Alphitonin
    		Control
    Alphitonin is a flavonoid and is also a metabolic intermediate that is formed during the catabolism of Quercetin (HY-18085) by the human gut bacteria E. ramulus.
    Alphitonin
  • HY-169330
    3β,5α,6β-Trihydroxycholanic acid
    3β,5α,6β-Trihydroxycholanic acid is a metabolite of 3β,5α,6β-Trihydroxycholestane (HY-W010934). 3β,5α,6β-Trihydroxycholanic acid can be used in research related to neurodegenerative diseases associated with lysosomal dysfunction.
    3β,5α,6β-Trihydroxycholanic acid
  • HY-Z4707
    Etoricoxib N1'-oxide
    Etoricoxib N1'-oxide is an Etoricoxib (HY-15321) metabolite. Etoricoxib N1'-oxide does not inhibit COX-1, nor does it significantly inhibit COX-2.
    Etoricoxib N1'-oxide
  • HY-135194
    Risperidone E-oxime
    Risperidone E-oxime is an impurity of Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively .
    Risperidone E-oxime
  • HY-126857R
    5-Hydroxyomeprazole (Standard)
    5-Hydroxyomeprazole (Standard) is the analytical standard of 5-Hydroxyomeprazole. This product is intended for research and analytical applications. 5-Hydroxyomeprazole is the major metabolite of Omeprazole (HY-B0113).
    5-Hydroxyomeprazole (Standard)
  • HY-G0002
    Lurasidone metabolite 14326
    		Chemical
    Lurasidone metabolite 14326 is an active metabolite of the atypical antipsychotic Lurasidone.
    Lurasidone metabolite 14326
  • HY-114992
    2-Propyl-2-pentenoic acid
    2-Propyl-2-pentenoic acid is a metabolite of Valproic acid (HY-10585). 2-Propyl-2-pentenoic acid has a facilitating action on the acquisition of conditioned behavior with negative reinforcement in mice.
    2-Propyl-2-pentenoic acid
  • HY-Y0801R
    2,6-Dihydroxybenzoic acid (Standard)
    2,6-Dihydroxybenzoic acid (Standard) is the analytical standard of 2,6-Dihydroxybenzoic acid (HY-Y0801). This product is used for research and analytical applications. 2,6-Dihydroxybenzoic acid is an aromatic compound containing phenolic hydroxyl groups and carboxyl groups, and it is a secondary metabolite of Salicylic acid (HY-B0167). 2,6-Dihydroxybenzoic acid is also present in olive oil wastewater.
    2,6-Dihydroxybenzoic acid (Standard)
  • HY-116029
    Tolmetin β-D-Glucuronide
    Tolmetin β-D-Glucuronide (Tolmetin glucuronide) is the major phase II metabolite of Tolmetin (HY-B1799).
    Tolmetin β-D-Glucuronide
  • HY-148083
    TBBPA-sulfate
    TBBPA-sulfate is metabolite of TBBPA. TBBPA has been reported to enhance adipogenesis by binding with the peroxisome proliferator-activated receptor gamma (PPARγ).
    TBBPA-sulfate
  • HY-138128
    Acetaminophen mercapturate
    Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor.
    Acetaminophen mercapturate
  • HY-W724091
    PB-22 N-pentanoic acid metabolite
    		Control
    PB-22 N-pentanoic acid metabolite is a metabolite of PB-22. PB-22 is a cannabinoid.
    PB-22 N-pentanoic acid metabolite
  • HY-W700620
    Hydroxymethyl dasatinib
    		99.92%
    Hydroxymethyl dasatinib (M24), a benzylhydroxy metabolite of Dasatinib (HY-10181), exhibits an IC50 of 46.7nM in K562 CML cells.
    Hydroxymethyl dasatinib
  • HY-I0678R
    Regorafénib N-oxyde (M2) (Standard)
    Quinocetone (Standard) is the analytical standard of Quinocetone. This product is intended for research and analytical applications. Quinocetone is a potent synthetic antimicrobial agent that is used for improving the feed efficiency and controlling dysentery in food-producing animals.
    Regorafénib N-oxyde (M2) (Standard)
  • HY-13318R
    Oseltamivir acid (Standard)
    Oseltamivir acid (Standard) is the analytical standard of Oseltamivir acid. This product is intended for research and analytical applications. Oseltamivir acid (GS 4071), the active metabolite of Oseltamivir phosphate, is an orally bioavailable, potent and selective inhibitor of influenza virus neuraminidase (IC50=2 nM) with activity against both influenza A and B viruses.
    Oseltamivir acid (Standard)
  • HY-131273R
    Febuxostat amide impurity (Standard)
    Febuxostat amide impurity (Standard) is the analytical standard of Febuxostat amide impurity. This product is intended for research and analytical applications. Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM
    Febuxostat amide impurity (Standard)
  • HY-135577R
    β-Apooxytetracycline (Standard)
    β-Apooxytetracycline (Standard) is the analytical standard of β-Apooxytetracycline. This product is intended for research and analytical applications. β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic.
    β-Apooxytetracycline (Standard)
  • HY-W703869
    5-Hydroxy NMT oxalate
    5-Hydroxy NMT (N-Methylserotonin) oxalate is a metabolite of 5-HT and belongs to the tryptamine class of compounds. Elevated levels of 5-Hydroxy NMT oxalate in plasma are associated with cocaine addiction.
    5-Hydroxy NMT oxalate
  • HY-165005
    14S(15R)-EET methyl ester
    		Control
    14S(15R)-EET methyl ester is an oxylipin and a cytochrome P450 metabolite of Arachidonic acid (HY-109590).
    14S(15R)-EET methyl ester
Cat. No. Product Name / Synonyms Application Reactivity